The Elusive Spermatogonial Stem Cell Marker?1
نویسندگان
چکیده
منابع مشابه
Defining the spermatogonial stem cell.
Through the use of donor cells from transgenic rats expressing GFP exclusively in the germline, we have defined culture conditions where male germ cells lose (on STO cells) or maintain (on MSC-1 cells) stem cell activity. A cadre of germ cell transcripts strikingly decrease in relative abundance as a function of testis age or culture time on STO cells, but only a subset of these transcripts (ap...
متن کاملSpermatogonial Stem Cell Niche and Spermatogonial Stem Cell Transplantation in Zebrafish
BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their ability to differentiate. METHODOLOGY/PRINCIPAL FINDINGS Here, we introduce zebrafish as a new model for the study of SSCs in vertebrates. Us...
متن کاملSpermatogonial stem cell isolation, storage, and transplantation.
The past 30 years have been marked by unparalleled accomplishments in the medical treatment of malignancy. Prior to advances in chemotherapeutic and radiation treatment, many oncologic conditions had dismal survival rates. Today, medical interventions have success rates that approach complete remission for many malignancies. An inadvertent complication of these therapies, however, has been the ...
متن کاملSpermatogonial Stem Cell Technology and Regenerative Medicine
Germ cell development begins with the characteristics of the primordial germ cells (PGCs) early in human fetal life. PGCs arise from the proximal epiblast and will replace to the extra embryonic mesoderm during the fourth and fifth week of embryonic development. By the finish of the fifth week to early sixth week, PGCs will embark for a second immigration via the dorsal mesenterium of the gut t...
متن کاملAdvances in spermatogonial stem cell transplantation.
Spermatogonial stem cell transplantation was first reported by Ralph Brinster's laboratory in 1994. It has proven to be a technological breakthrough in the study of both stem cells and Sertoli cell-germ cell interactions. This technique can be used to transfer testicular stem cells successfully from one animal to another of the same species (referred to as syngeneic transplants) and sometimes t...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2011
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.111.093146